Can an ugly 20 year old guy ever hope to make a single friend in his life?

Come on now, don't be so hard on yourself. Things will get better, but don't listen to this jerk above me. He doesn't know what he is talking about. People's looks don't affect who I make friends with, and sooner or later, if you push yourself to always be outgoing, you will find people who want to be friends with you.